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Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed in Russia. It is derived from the natural immunomodulatory peptide tuftsin, but modified for greater stability. Selank has been studied for its anxiolytic (anti-anxiety), nootropic, and neuroprotective properties. It is thought to work by modulating neurotransmitter systems (including serotonin and dopamine) and influencing the expression of brain-derived neurotrophic factor (BDNF). Selank is approved for medical use in Russia for anxiety and stress-related conditions but remains experimental and is not FDA-approved in the United States.
How It Is Used in Research Settings
- Studied for reducing anxiety and improving stress resilience.
- Explored for enhancing learning, memory, and cognitive performance.
- Investigated for immune-modulating effects through cytokine regulation.
- Examined for neuroprotective potential in models of brain injury and neurodegeneration.
Proposed Uses (Research Areas)
- Anxiety and mood disorder research.
- Nootropic and cognitive enhancement studies.
- Immune modulation models.
- Neurodegenerative disease and brain injury research.
How It Is Dosed in Research Settings
- Intranasal: The most common route; studied at 200–900 mcg per day, divided into 2–3 doses.
- Injectable: Less commonly researched; doses of 200–500 mcg daily subcutaneously have been reported.
- Cycle length: Protocols typically run 2–4 weeks, though some extend longer in cognitive and mood research models.
- Handling: Supplied as solution or lyophilized powder; stored refrigerated and protected from light.
Important Considerations
- Regulatory status: Approved in Russia for certain medical uses; not FDA-approved in the U.S. or most Western countries.
- Evidence base: Supported by preclinical studies and some clinical data in Russia; Western validation is limited.
- Safety: Reported as well tolerated in research, with few side effects (mild nasal irritation, headache, or fatigue). Long-term safety data is lacking.
Disclaimer
This material is provided for educational purposes only and summarizes published research on Selank.
It is not medical advice. Selank is experimental, not FDA-approved in the United States, and should not be viewed as a therapy for medical use.
This peptide is for research use only.